Laufs, U., Wassmann, S., Czech, T., Mnzel, T., Eisenhauer, M., Bhm, M., & Nickenig, G
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) tends to drive monocytes/macrophages toward an M1 state
This shift in metabolic preferences has been further validated in specific cell lines, such as A549 and H1299, where SLC7A11 knockdown led to an increase in OXPHOS and a decrease in glycolysis ( in vivo , within a tumor microenvironment, where the metabolic reprogramming associated with altered SLC7A11 expression was evident (61)